{"id":58093,"date":"2019-03-25T00:00:00","date_gmt":"2019-03-24T22:00:00","guid":{"rendered":"https:\/\/richardvanhooijdonk.com\/blog\/edible-tech-sensor-embedded-and-bluetooth-enabled-smart-pills-herald-the-future-of-healthcare\/"},"modified":"2021-06-04T10:15:27","modified_gmt":"2021-06-04T08:15:27","slug":"edible-tech-sensor-embedded-and-bluetooth-enabled-smart-pills-herald-the-future-of-healthcare","status":"publish","type":"post","link":"https:\/\/blog.richardvanhooijdonk.com\/en\/edible-tech-sensor-embedded-and-bluetooth-enabled-smart-pills-herald-the-future-of-healthcare\/","title":{"rendered":"Edible tech: sensor-embedded and bluetooth-enabled smart pills herald the future of healthcare"},"content":{"rendered":"<ul class=\"bold-list\">\n<li>MIT\u2019s edible wireless device releases drugs to aid in early intervention<\/li>\n<li>This smart pill injects insulin directly into patients\u2019 stomachs<\/li>\n<li>Proteus launched a smart pill program to improve medication adherence for cancer patients<\/li>\n<li>Sensor-embedded pills could become a useful tool in detecting and monitoring digestive disorders<\/li>\n<li>Smart pills are facing regulatory hurdles<\/li>\n<li>Is edible tech the medicine of the future?<\/li>\n<\/ul>\n<p>There have been a lot of innovations dubbed as the next big thing in the medical world over the years, but <a href=\"https:\/\/blog.richardvanhooijdonk.com\/en\/blog\/a-smart-pill-that-tells-you-if-youre-sick-the-future-of-healthcare\/\">smart pill technology<\/a> might just top the list. This rather innovative method of drug delivery involves sensors and cameras embedded into tiny edible devices. Such medical devices ensure better diagnostics, monitoring, and treatment of life-threatening medical conditions by allowing doctors to monitor their patients\u2019 body functions in real time. Furthermore, since this tech has the ability to deliver medication into specific parts of the patient\u2019s body, it eliminates many side-effects associated with traditional drug delivery.<\/p>\n<p>Along with growing demand for real-time patient monitoring and less invasive drug delivery, other factors, such as the aging population and the increased incidence of gastrointestinal diseases are driving the growth of the smart pills market. In 2016, the global smart pills market <a href=\"https:\/\/www.pharmaceutical-technology.com\/news\/easy-swallow-rapid-growth-smart-pill-market-expected-2025\/\">was<\/a> worth $779.9 million, and by 2025, it\u2019s expected to reach a staggering $3 billion. Though the technology still has a lot of room for improvement, researchers are coming up with highly advanced solutions that have great potential to change the way doctors diagnose and treat various conditions.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-66817\" src=\"https:\/\/blog.richardvanhooijdonk.com\/wp-content\/uploads\/sites\/4\/2019\/03\/Global-smart-pills-market-1-300x113.png\" alt=\"Infographic showing the value of the global smart pills market in 2016, and its expected value in 2025.\" width=\"800\" height=\"302\" srcset=\"https:\/\/blog.richardvanhooijdonk.com\/wp-content\/uploads\/2019\/03\/Global-smart-pills-market-1-300x113.png 300w, https:\/\/blog.richardvanhooijdonk.com\/wp-content\/uploads\/2019\/03\/Global-smart-pills-market-1-768x290.png 768w, https:\/\/blog.richardvanhooijdonk.com\/wp-content\/uploads\/2019\/03\/Global-smart-pills-market-1-1024x387.png 1024w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<h2>MIT\u2019s edible wireless device releases drugs to aid in early intervention<\/h2>\n<p>One of those solutions is the brainchild of researchers and experts from MIT, the Draper Laboratory, and Brigham and Women\u2019s Hospital, who <a href=\"https:\/\/blog.hackster.io\/mit-researchers-develop-an-ingestible-sensor-capsule-that-communicates-over-bluetooth-d9c09d6f4285\">created<\/a> an ingestible capsule made with 3D printing technology that relays data via Bluetooth. After the capsule is swallowed, it unfolds its two Y-shaped arms and lodges into the patient\u2019s stomach, where it can stay for a month. During that time, the capsule collects information about the patient\u2019s body and transmits the data to the user\u2019s smartphone. For patients who need early intervention in case of a fever, or those who are at a risk of an infection, this tech proves to be a more efficient alternative to traditional drugs. For instance, once swallowed, the device can monitor the patient\u2019s body temperature over the course of a couple of weeks, and in case it detects that the temperature is too high or too low, it can release a drug to ease the symptoms. The new device could be instructed to keep track of any relevant changes within the human body, such as allergic reactions or infection, and release drugs as a response to the detected symptoms.<\/p>\n<p>So far, the researchers have <a href=\"https:\/\/www.digitaltrends.com\/cool-tech\/mit-smart-capsule-fever\/\">tested<\/a> their innovation only on pigs. During the experiment, the device \u201ccommunicated the core body temperature of the pig and was triggered to carry out timed drug release\u201d. In the future, they also plan to equip the tech with sensors that will measure the patient\u2019s heart rate and breathing rate. The only downside of this technology is that it\u2019s currently powered by a silver-oxide battery, known to contain poisonous mercury. Luckily, safer, mercury-free batteries are being developed, and the researchers are also considering other sources of energy to power the device, such as stomach acid.<\/p>\n<h2>This smart pill injects insulin directly into patients\u2019 stomachs<\/h2>\n<p>Another innovation developed by MIT could improve the lives of millions of people suffering from diabetes, a condition in which the human body can\u2019t properly produce or use the hormone insulin. The most common way to take insulin for people with type 1 diabetes is through injections, but the process can be unpleasant and painful. So, MIT\u2019s researchers came up with an alternative \u2013 a smart pill called SOMA, or self-orienting millimeter-scale applicator. The SOMA pill contains the same type of insulin used in conventional injection kits, the only difference being that the insulin in SOMA is compressed. The size of a blueberry, the pill consists of a capsule and a tiny needle made almost exclusively from freeze-dried insulin. Once the pill is ingested, its sugar-based coating is dissolved by water, and it releases the needle and injects it into the stomach. And since the stomach wall has no pain receptors, the process is completely painless.<\/p>\n<p><iframe title=\"A self-orienting millimeter-scale applicator (SOMA) for oral delivery of insulin and other biologics\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/w7UTwEPYD4M?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Thanks to its shape, SOMA can navigate on its own in the stomach, injecting the needle and releasing the insulin in just the right spot. As <em>TechCrunch<\/em> <a href=\"https:\/\/techcrunch.com\/2019\/02\/07\/mits-insulin-pill-could-replace-injections-for-people-with-type-2-diabetes\/\">reveals<\/a>, the researchers were inspired by the leopard tortoise, a type of tortoise found in Africa that \u201chas a shell with a high, steep dome, allowing it to right itself if it rolls onto its back\u201d. The team used computer modelling to create a pill with a similar shape, allowing the capsule \u201cto reorient itself even in the dynamic environment of the stomach\u201d. It takes around an hour for the insulin to be fully released into the bloodstream, after which the capsule breaks down in the digestive tract. Just like their previous innovation, MIT\u2019s scientists first tested the pill on pigs. The tests revealed that the tech was able to decrease blood sugar to the same levels as those achieved with traditional insulin injections. Though the innovation could change the lives of diabetic patients, it\u2019s still unknown when human trials will begin or if the pill will be commercialised anytime soon.<\/p>\n<h2>Proteus launched a smart pill program to improve medication adherence for cancer patients<\/h2>\n<p>MIT\u2019s researchers aren\u2019t the only ones exploring the potential of smart pills. Proteus, a company that specialises in digital medicine, is just one of the companies that share a similar interest. Proteus is best known for the development of Abilify MyCite, the first digital pill approved by the Food and Drug Administration (FDA) in 2017. The sensor-equipped drug was <a href=\"https:\/\/www.statnews.com\/2019\/01\/17\/a-digital-pill-for-cancer-patients-is-rolled-out-for-the-first-time-in-hopes-of-improving-outcomes\/\">created<\/a> for patients with schizophrenia and bipolar disorder. For patients who struggle to take medications regularly, making sure they take the right dose at the right time is a crucial part of the treatment. Proteus is now determined to bring the same level of convenience to oncology patients, too. For this reason, the company partnered up with the Minneapolis-based health system Fairview Health Services and the University of Minnesota.<\/p>\n<p>The program involves patients suffering from colorectal cancer in stage 3 or stage 4. However, instead of taking their regular chemotherapy drug, the patients are given a sensor-embedded version of the same medication that notifies the doctor when the medicine has been ingested. Once the pill is swallowed, the sensor will activate and send a signal to a patch worn on the patient\u2019s torso. The patch will then transmit the data to an online portal. The data will show the time of day when the medication was taken, the type of drug, and the size of the dose. The program currently involves seven patients, but the company plans to expand it to 750 patients with different cancers across the US. And best of all, the cost of this treatment for patients is no higher than regular chemotherapy drugs.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=G0LR_g0Iw48<\/p>\n<h2>Sensor-embedded pills could become a useful tool in detecting and monitoring digestive disorders<\/h2>\n<p>Besides being an ideal drug delivery solution, smart pills could also revolutionise the way doctors diagnose various disorders. One such innovation was unveiled by a group of Australian researchers, who created an electronic capsule designed to analyse the composition of gas in the large and small intestine and send the data to an external device in 5-minute intervals. In a study <a href=\"https:\/\/qz.com\/1174494\/an-electronic-pill-to-analyze-the-gas-in-your-gut\/\">published<\/a> in the journal \u00a0in 2018, the researchers revealed how they used a wireless capsule equipped with sensors, a battery, a thermometer, and a radio transmitter to monitor the production of gasses in the human digestive tract. Thanks to the sensors, the pill is able to detect the levels of oxygen, hydrogen, and carbon dioxide.<\/p>\n<p>The sensor-embedded pill was successfully tested on human volunteers. During the testing, the researchers put two participants on a high-fibre diet, two on a low-fibre diet, and one was monitored both on a high- and low-fibre diet. <a href=\"https:\/\/qz.com\/1174494\/an-electronic-pill-to-analyze-the-gas-in-your-gut\/\">According to<\/a> the researchers, data from the device, which is only 2.5 centimetres long, \u201creflected expected changes in the gut microbiomes of a high-fiber diet: different species flourished after a couple of high-fiber days\u201d. The traditional method of monitoring the gut is based on endoscopy, in which a long, flexible tube is inserted through a patient\u2019s mouth or anus. The new solution would be less invasive and could help doctors to identify whether specific dietary changes are effective. Plus, none of the participants experienced any side-effects from ingesting the pill, further bolstering the potential of this innovation.<\/p>\n<figure id=\"attachment_41223\" aria-describedby=\"caption-attachment-41223\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-41223 size-full\" src=\"https:\/\/blog.richardvanhooijdonk.com\/wp-content\/uploads\/sites\/4\/2019\/05\/pill-2.jpg\" alt=\"Man in white laboratory suit wearing protective spectacles looking at something through a microscope\" width=\"800\" height=\"526\" \/><figcaption id=\"caption-attachment-41223\" class=\"wp-caption-text\">Edible electronics have the potential to do all kinds of amazing stuff, but it may take some time before this technology becomes mainstream.<\/figcaption><\/figure>\n<h2>Smart pills are facing regulatory hurdles<\/h2>\n<p>Edible electronics have the potential to do all kinds of amazing stuff, but it may take some time before this technology becomes mainstream. Like any other technology that can capture and send data, digital pills are also accompanied by privacy concerns. Since the majority of newly-developed sensor-embedded pills can connect to a smartphone, allowing healthcare professionals to access the data, there\u2019s always the risk of someone misusing it.<\/p>\n<p>This is why getting approval for the new tech takes a lot of time. And the FDA recently made some changes to the process. It released a draft guidance document for tech companies and developers that <a href=\"https:\/\/futurism.com\/fda-regulate-smart-pills\">advises<\/a> smart pill manufacturers to identify their innovations as either \u201cdevices or pharmaceuticals but not both\u201d. When submitting approval processes, developers have a tendency to submit multiple applications, because it <a href=\"https:\/\/www.mobihealthnews.com\/content\/fdas-new-draft-guidance-could-hinder-applications-digital-combination-products\">allows<\/a> them to \u201censure an appropriate risk-based review for both the device constituent part as well as the drug constituent part\u201d. However, with FDA\u2019s most recent guidelines, scientists are required to choose just one category, which \u201cmeans that the device constituent part might end up overregulated\u201d.<\/p>\n<p>And the situation isn&#8217;t much better in the EU, either. It also recently introduced certain changes to its Medical Device Regulation (formerly Medical Devices Directive), which <a href=\"https:\/\/www.regdesk.co\/major-differences-eu-mdr-mdd\/\">stipulates<\/a> that \u201cAll devices containing substances that will be introduced to and\/or absorbed by the body will rely on a totally different classification system\u201d than the traditional classification system. This means that substance-based medical devices could be classified as higher-risk, and therefore fall under more scrutiny.<\/p>\n<h2>Is edible tech the medicine of the future?<\/h2>\n<p>In a world where everything is becoming connected, the development of edible electronic pills should come as no surprise. This small piece of technology that can communicate with caregivers and share information about a patient\u2019s condition has received a lot of scientific and media attention. Although most of these solutions are still in the early research and testing stages, they offer immense potential for <a href=\"https:\/\/richardvanhooijdonk.com\/en\/keynote\/the-future-of-healthcare\/\">the future of healthcare<\/a>. Patients will no longer have to undergo painful procedures in their treatment. By simply swallowing a tiny pill, their bodies will receive the right dose of medication at the right time. It could help patients with various conditions to finally have a normal life, with no injections and other traditional medical tools. Medicine is ripe for a radical change, and a new generation of ingestible technology is moving the industry toward a future of better and more efficient care and treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>MIT\u2019s edible wireless device releases drugs to aid in early intervention This smart pill injects insulin directly into patients\u2019 stomachs Proteus launched a smart pill program to improve medication adherence for cancer patients Sensor-embedded pills could become a useful tool in detecting and monitoring digestive disorders Smart pills are facing regulatory hurdles Is edible tech [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":51995,"parent":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[2872],"tags":[4507,4571,4508],"article-type":[],"trends":[],"class_list":["post-58093","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-healthcare","tag-smart-pill","tag-technology-en-2","tag-wireless-device"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Edible tech: sensor-embedded and bluetooth-enabled smart pills herald the future of healthcare - Richard van Hooijdonk Blog<\/title>\n<meta name=\"description\" content=\"Edible tech could make drug delivery and monitoring processes easier and less invasive, with recent 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